Detecting genetic interactions for quantitative traits with U-statistics

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Detecting Gene-Gene Interactions Associated with Multiple Complex Traits with U-Statistics

Many complex diseases, such as psychiatric and behavioral disorders, are commonly characterized through various measurements that reflect physical, behavioral and psychological aspects of diseases. While it remains a great challenge to find a unified measurement to characterize a disease, the available multiple phenotypes can be analyzed jointly in the genetic association study. Simultaneously ...

متن کامل

Detecting Genetic Interactions for Quantitative Traits Using m-Spacing Entropy Measure

A number of statistical methods for detecting gene-gene interactions have been developed in genetic association studies with binary traits. However, many phenotype measures are intrinsically quantitative and categorizing continuous traits may not always be straightforward and meaningful. Association of gene-gene interactions with an observed distribution of such phenotypes needs to be investiga...

متن کامل

The role of genetic interactions in yeast quantitative traits

Joshua Bloom, Iulia Kotenko, Meru Sadhu, Sebastian Treusch, Frank W. Albert, Leonid Kruglyak Department of Human Genetics, University of California, Los Angeles, Los Angeles, California, USA Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, California, USA Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544 Department of ...

متن کامل

An aggregating U-Test for a genetic association study of quantitative traits

We propose a novel aggregating U-test for gene-based association analysis. The method considers both rare and common variants. It adaptively searches for potential disease-susceptibility rare variants and collapses them into a single "supervariant." A forward U-test is then used to assess the joint association of the supervariant and other common variants with quantitative traits. Using 200 sim...

متن کامل

Detecting epistasis with the marginal epistasis test in genetic mapping studies of quantitative traits

Epistasis, commonly defined as the interaction between multiple genes, is an important genetic component underlying phenotypic variation. Many statistical methods have been developed to model and identify epistatic interactions between genetic variants. However, because of the large combinatorial search space of interactions, most epistasis mapping methods face enormous computational challenges...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Genetic Epidemiology

سال: 2011

ISSN: 0741-0395

DOI: 10.1002/gepi.20594